Name：Yisui Xia

Position：Professor

E-mail：[email protected]

Personal Statement:

Dr. Yisui Xia, Professor, and doctoral supervisor. Dr. Xia was selected into NSFC Science Fund Program for Excellent Young Scientists (Overseas) in 2024. Dr. Xia obtained his Ph.D. from the College of Biological Sciences at China Agricultural University in 2016. From 2016 to 2023, and worked as a postdoctoral researcher in the Karim Labib laboratory at the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee. In 2023, Dr. Xia e joined the School of Basic Medical Sciences at the Health Science Center of Shenzhen University, and in 2024, he was appointed as a professor.

Over the years, Dr. Xia has been dedicated to uncovering the molecular mechanisms of the eukaryotic DNA replication process. His representative achievements include: identifying the first replication initiation factor that is specific and essential in higher eukaryotes; revealing the separation and activation mechanism of the yeast replication helicase CMG; and in vitro reconstitution of the core reaction of metazoan replication termination. Dr. Xia has published a total of 9 papers in high quality journals such as Science, the EMBO Journal, Cell Reports, and EMBO Reports as the first or corresponding (including co-corresponding) author..

Research Interests:

DNA replication

Genome stability

Chromosome replication

Research Projects:

2025.1-2027.12 NSFC Science Fund Program for Excellent Young Scientists (Overseas), 1.0 million yuan.

Selected Peer-reviewed Publications:

1. Xia, Y.^#, Sonneville, R. ^#, Jenkyn-Bedford, M. ^#, Ji, L., Alabert, C., Hong, Y. *, Yeeles, J.T.P. *, Labib, K.P.M. * (2023). DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Science, 381(6664):eadi4932.

2. Xia, Y. ^#, Fujisawa, R., Deegan, T.D., Sonneville, R.*, and Labib, K.P.M.* (2021). TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans. EMBO J, e108053.

3. Xia, Y.* (2021). The Fate of Two Unstoppable Trains After Arriving Destination: Replisome Disassembly During DNA Replication Termination. Front Cell Dev Biol 9, 658003.

4. Quan, Y.^#, Xia, Y. ^#, Liu, L.^#, Cui, J., Li, Z., Cao, Q., Chen, X.S., Campbell, J.L., and Lou, H.* (2015). Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase. Cell Rep 13, 2576-2586. 

5. Wan, L. ^#, Lou, J. ^#, Xia, Y. ^#, Su, B., Liu, T., Cui, J., Sun, Y., Lou, H.*, and Huang, J.* (2013). hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Rep 14, 1104-1112. (F1000)